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Neier, Reinhard
Nom
Neier, Reinhard
Affiliation principale
Fonction
Professeure ordinaire
Email
Reinhard.Neier@unine.ch
Identifiants
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4 Résultats
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- PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1](2007)
;Simone, Jean-Mary ;Loiseau, François ;Carcache, David ;Bobal, Pavel ;Jeanneret-Gris, JulieA malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues. - PublicationAccès libreRadical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid(2007)
;Loiseau, François ;Simone, Jean-Mary ;Carcache, David ;Bobal, PavelFree radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alcohol function was introduced in one or two steps in 86% yield. For the introduction of the second chain with the ester function two different coupling methods were tested. Starting from the advanced intermediates obtained nonactin derivatives can be prepared by catalytic hydrogenation of the furan ring. - PublicationAccès libreMalonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1](2007)
;Simone, Jean-Mary ;Loiseau, François ;Carcache, David ;Bobal, Pavel ;Jeanneret-Gris, JulieA malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues. - PublicationAccès libreThe chemical synthesis of porphobilinogen an important intermediate of the biosynthesis of the "pigments of life"(1997)
;Bobal, PavelPorphobilinogen is the second dedicated intermediate in the biosynthesis of «pigments of life». Only very few alkylpyrroles have been isolated from natural sources so far. The absence of stabilising substituents confers to porphobilinogen a high reactivity. The chemical synthesis of porphobilinogen had to take its sensitivity into account. The published synthesis of this unusual pyrrole are reviewed. The synthetic strategies used are analysed and compared with the biosynthesis.