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Süss-Fink, Georg

Nom
Süss-Fink, Georg
Affiliation principale
Fonction
Professeur ordinaire
Email
georg.suess-fink@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/385

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  • Publication
    Métadonnées seulement
    Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(?6-arene)Ru(p-SC5H4NH)3]2+
    (2008)
    Gras, Michael
    ;
    Therrien, Bruno 
    ;
    Süss-Fink, Georg 
    ;
    Stepnicka, Petr
    ;
    Renfrew, Anna K.
    ;
    Dyson, Paul J.
    The cationic complexes [(?6-arene)Ru(SC5H4NH)3]2+, arene being C6H6 (1), MeC6H5 (2), p-iPrC6H4Me (3) or C6Me6 (4), have been synthesized from the reaction of 4-pyridinethiol with the corresponding precursor (?6-arene)2Ru2(?2-Cl)2Cl2 and isolated as the chloride salts. The single-crystal x-ray structure of [4](PF6)2 reveals three 4-pyridinethiol moieties coordinated to the ruthenium center through the sulfur atom, with the hydrogen atom transferred from the sulfur to the nitrogen atom. The electrochem. study of 1-4 shows a clear correlation between the Ru(II)/Ru(III) redox potentials and the no. of alkyl substituents at the arene ligand (E°' (RuII/III): 1 > 2 > 3 > 4), whereas the cytotoxicity towards A2780 ovarian cancer cells follows the series 4 > 1 > 3 > 2, the hexamethylbenzene deriv. 4 being the most cytotoxic one. The corresponding reaction of the ortho-isomer, 2-pyridinethiol, with (?6-C6Me6)2Ru2(?2-Cl)2Cl2 does not lead to the expected 2-pyridinethiolato analog, but yields the neutral complex (?6-C6Me6)Ru(?2-SC5H4N)(?1-SC5H4N) (5). The analogous complex (?6-C6Me6)Ru(?2-SC9H6N)-(?1-SC9H6N) (6) is obtained from the similar reaction with 2-quinolinethiol. [on SciFinder(R)]