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Süss-Fink, Georg

Nom
Süss-Fink, Georg
Affiliation principale
Fonction
Professeur ordinaire
Email
georg.suess-fink@unine.ch
Identifiants
https://libra.unine.ch/handle/123456789/385

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  • Publication
    Métadonnées seulement
    Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity
    (2008)
    Auzias, Mathieu
    ;
    Therrien, Bruno 
    ;
    Süss-Fink, Georg 
    ;
    Stepnicka, Petr
    ;
    Ang, Wee Han
    ;
    Dyson, Paul J.
    Reaction of the dimers [Ru(?6-arene)Cl2]2 (arene = C6H6, C6H5Me, p-iPrC6H4Me, C6Me6) with 2 equiv of the ferrocenoyl pyridine (NC5H4(OOCC5H4FeC5H5)-4) affords Ru(II) complexes [Ru(?6-arene)Cl2(NC5H4OOCC5H4FeC5H5)] (arene = C6H6 (1, 85% yield), C6H5Me (2, 81%), p-iPrC6H4Me (3, 91%), C6Me6 (4, 38%)) or with 1 equiv of the dipyridylferrocene deriv. ligand, 1,1'-ferrocene dicarboxylic acid pyridin-4-yl ester (NC5H4OOCC5H4FeC5H4COOC5H4N,) gives [Ru(?6-arene)Cl2]2(NC5H4OOCC5H4FeC5H4COOC5H4N) (arene = p-iPrC6H4Me (5, 74%), C6Me6 (6, 92%)). The mol. structures of these complexes was confirmed by single-crystal x-ray structure anal. of complex 4 as a representative example. The redox properties and in vitro anticancer activities of complexes 1-6 were studied. All the compds. are moderately cytotoxic toward the A2780 and A2780cisR (cisplatin-resistant) human ovarian carcinoma cell lines. The diruthenium arene complexes 5 and 6 are about twice as active as their mononuclear analogs 3 and 4. Cyclic voltammetry revealed a good correlation of the RuII/RuIII redox potentials of 1-4 and the no. of alkyl substituents in the arene ligand. [on SciFinder(R)]
  • Publication
    Métadonnées seulement
    Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer
    (2008)
    Schmitt, Frederic
    ;
    Govindaswamy, Padavattan
    ;
    Süss-Fink, Georg 
    ;
    Ang, Wee Han
    ;
    Dyson, Paul J.
    ;
    Juillerat-Jeanneret, Lucienne
    ;
    Therrien, Bruno 
    Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic agents. The dinuclear areneruthenium complexes [Ru(?6-arene)(?-Cl)Cl]2 (arene = C6H6, C6H5CH3, p-iPrC6H4Me, C6Me6, and 1,4-C6H4(COOEt)2) react with TPP in MeOH to give the corresponding tetranuclear complexes [Ru4(?6-arene)4(TPP)Cl8] (arene = C6H6 (1, 56% yield), C6H5CH3 (2, 70%), p-iPrC6H4Me (3, 70%), C6Me6 (4, 79%), 1,4-C6H4(COOEt)2 (5, 73%)). The dinuclear p-cymeneosmium complex [Os(?6-p-iPrC6H4Me)(?-Cl)Cl]2 reacts with TPP to form the tetranuclear areneosmium complex [Os4(?6-p-iPrC6H4Me)4(TPP)Cl8] (6) in 47% yield. The isoelectronic Rh and Ir pentamethylcyclopentadienyl derivs. [Rh4(?5-C3Me5)4(TPP)Cl8] (7, 73%) and [Ir4(?5-C3Me5)4(TPP)Cl8] (8, 83%) were obtained in MeOH from the reaction of [M(?5-C5Me5)(?-Cl)Cl]2 (M = Rh, Ir) with TPP. The mol. structures of 4 and 7 were detd. by x-ray crystallog. The biol. effects of all these derivs. were assessed on human melanoma tumor cells, and their cellular uptake and intracellular localization were detd. All mols., except the Rh complex which was not cytotoxic, demonstrated comparable cytotoxicity in the absence of laser irradn. The Ru complexes exhibited excellent phototoxicities toward melanoma cells when exposed to laser light at 652 nm. Cellular uptake and localization microscopy studies of [Ru4(?6-C6H5CH3)4(TPP)Cl8] and [Rh4(?5-C5Me5)4(TPP)Cl8] revealed that they accumulated in the melanoma cell cytoplasm in granular structures different from lysosomes. The fluorescent porphyrin moiety and the metal component were localized in similar structures within the cells. Thus, the porphyrin areneruthenium(II) derivs. represent a promising new class of organometallic photosensitizers able to combine chemotherapeutic activity with photodynamic therapeutic treatment of cancer. [on SciFinder(R)]
  • Publication
    Accès libre
    Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters
    (2007)
    Therrien, Bruno 
    ;
    Ang, Wee Han
    ;
    Chérioux, Frédéric
    ;
    Vieille-Petit, Ludovic
    ;
    Juillerat-Jeanneret, Lucienne
    ;
    Süss-Fink, Georg 
    ;
    Dyson, Paul J.
    The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3 (μ-H)3 (μ3-O)][BF4], [(η6-C6H6)4Ru4 (μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4 (μ-H)4][BF4]2 and [(η6-C6H6)4Ru4 (μ-H)3 (μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4 (μ-H)4][PF6]2 is also reported.