Water-Soluble Arene Ruthenium Complexes
Responsable du projet Georg Süss Fink
Collaborateur Michael Gras
Marie Anne Flore Ibao
Julien Freudenreich
Résumé The present research project focuses on the synthesis and structural characterization of new di- and multinuclear arene ruthenium complexes that are soluble in water and inert towards hydrolysis, with the aim of exploiting their inherent catalytic or biological potential. Background Although being the cheapest of all noble metals, ruthenium has almost no industrial application and was only scarcely used in catalytic reactions, until the discovery of highly enantioselective ruthenium-based hydrogenation catalysts by R. Noyori and of efficient ruthenium-based olefin metathesis catalysts by R. H. Grubbs. These two major discoveries led to the Nobel prizes of 2001 and 2005 and also stimulated the coordination chemistry of ruthenium. Aim Within this project, we propose to work on two main topics involving two Ph. D. students: Dinuclear Arene Ruthenium Complexes with Thiolato and Selenolato Bridges as well as Arene Ruthenium Cages with Various Tritopic Connecting Units. Significance While water-soluble organometallics in general are still very rare, arene ruthenium complexes with this particular property, the chemistry of which we have pioneered, open new perspectives for use as catalysts in aqueous solution and as potential anti-cancer drugs. Keywords Ruthenium, Dinuclear complexes, Trinuclear clusters, Arene ruthenium cages, Catalysis, Water-soluble organometallics, Anti-cancer properties
Mots-clés Dinuclear complexes, Trinuclear clusters, Hexanuclear cages, Catalysis, Water-soluble organometallics, Ruthenium, Anticancer properties, Arene ruthenium cages, Anti-cancer properties
Type de projet Recherche fondamentale
Domaine de recherche Chimie inorganique
Source de financement FNS - Encouragement de projets (Div. I-III)
Etat Terminé
Début de projet 1-10-2010
Fin du projet 30-9-2012
Budget alloué 242'020.00
Autre information http://p3.snf.ch/projects-131844#
Contact Georg Süss-Fink