Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity
Author(s)
Auzias, Mathieu
Stepnicka, Petr
Ang, Wee Han
Dyson, Paul J.
Date issued
2008
In
Inorg. Chem.
Vol
2
No
47
From page
578
To page
583
Subjects
arenedichlororuthenium dimer reaction ferrocenoyl pyridine crystal structure ferrocenoylpyridine arene ruthenium prepn cytotoxicity cyclic voltammetry mol structure ferrocenoylpyridine arene ruthenium prepn cytotoxicity cyclic voltammetry ferrocenoylpyridine arene ruthenium cytotoxicity ovarian carcinoma cisplatin resistant
Abstract
Reaction of the dimers [Ru(?6-arene)Cl2]2 (arene = C6H6, C6H5Me, p-iPrC6H4Me, C6Me6) with 2 equiv of the ferrocenoyl pyridine (NC5H4(OOCC5H4FeC5H5)-4) affords Ru(II) complexes [Ru(?6-arene)Cl2(NC5H4OOCC5H4FeC5H5)] (arene = C6H6 (1, 85% yield), C6H5Me (2, 81%), p-iPrC6H4Me (3, 91%), C6Me6 (4, 38%)) or with 1 equiv of the dipyridylferrocene deriv. ligand, 1,1'-ferrocene dicarboxylic acid pyridin-4-yl ester (NC5H4OOCC5H4FeC5H4COOC5H4N,) gives [Ru(?6-arene)Cl2]2(NC5H4OOCC5H4FeC5H4COOC5H4N) (arene = p-iPrC6H4Me (5, 74%), C6Me6 (6, 92%)). The mol. structures of these complexes was confirmed by single-crystal x-ray structure anal. of complex 4 as a representative example. The redox properties and in vitro anticancer activities of complexes 1-6 were studied. All the compds. are moderately cytotoxic toward the A2780 and A2780cisR (cisplatin-resistant) human ovarian carcinoma cell lines. The diruthenium arene complexes 5 and 6 are about twice as active as their mononuclear analogs 3 and 4. Cyclic voltammetry revealed a good correlation of the RuII/RuIII redox potentials of 1-4 and the no. of alkyl substituents in the arene ligand. [on SciFinder(R)]
Publication type
journal article