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Aqueous oxidation of alcohols catalyzed by artificial metalloenzymes based on the biotin–avidin technology
Auteur(s)
Thomas, Christophe M.
Letondor, Christophe
Humbert, Nicolas
Ward, Thomas R.
Date de parution
2006-10-10
In
Journal of Organometallic Chemistry, 2005/690/4488-4491
Résumé
Based on the incorporation of biotinylated organometallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary alcohols using <i>tert</i>-butylhydroperoxide as oxidizing agent. In the presence of avidin as host protein, the biotinylated aminosulfonamide ruthenium piano stool complex <b>1</b> (0.4 mol%) catalyzes the oxidation of <i>sec</i>-phenethyl alcohol at room temperature within 90 h in over 90% yield. Gel electrophoretic analysis of the reaction mixture suggests that the host protein is not oxidatively degraded during catalysis.
Identifiants
Type de publication
journal article
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