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Arene–ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η<sup>6</sup>-arene)(NC<sub>5</sub>H<sub>4</sub>CH<sub>2</sub>NHOC-C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>5</sub>)Cl<sub>2</sub>] and [Ru(η<sup>6</sup>-arene)(NC<sub>3</sub>H<sub>3</sub>N(CH<sub>2</sub>)<sub>2</sub>O<sub>2</sub>C–C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>5</sub>)Cl<sub>2</sub>]
Auteur(s)
Auzias, Mathieu
Gueniat, Joël
Renfrew, Anna K.
Dyson, Paul J.
Date de parution
2009
In
Journal of Organometallic Chemistry, Elsevier, 2009/694/6/855-861
Résumé
Arene–ruthenium complexes of general formula [Ru(η<sup>6</sup>-arene)(L)Cl<sub>2</sub>] where L = NC<sub>5</sub>H<sub>4</sub>CH<sub>2</sub>NHOC-C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>5</sub>, arene = <i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me (<b>1</b>) or C<sub>6</sub>Me<sub>6</sub> (<b>2</b>); L = NC<sub>3</sub>H<sub>3</sub>N(CH<sub>2</sub>) <sub>2</sub>O<sub>2</sub>C–C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>5</sub>, arene = <i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me (<b>3</b>) or C<sub>6</sub>Me<sub>6</sub> (<b>4</b>), and diruthenium–arene complexes of general formula [Ru(η<sup>6</sup>-arene)Cl<sub>2</sub>] <sub>2</sub> (L) where L = 1,1′-(NC<sub>5</sub>H<sub>4</sub>CH<sub>2</sub>NHOC)<sub>2</sub>-C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>4</sub>, arene = <i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me (<b>5</b>) or C<sub>6</sub>Me<sub>6</sub> (<b>6</b>); L = 1,1′-(NC<sub>3</sub>H<sub>3</sub>N(CH<sub>2</sub>)<sub>2</sub>O<sub>2</sub>C)<sub>2</sub>–C<sub>5</sub>H<sub>4</sub>FeC<sub>5</sub>H<sub>4</sub>, arene = <i>p-<sup>i</sup></i>PrC<sub>6</sub>H<sub>4</sub>Me (<b>7</b>) or C<sub>6</sub>Me<sub>6</sub> (<b>8</b>) have been synthesized and characterized. The molecular structures of <b>1</b> and <b>3</b> were confirmed by single-crystal X-ray diffraction. The <i>in vitro</i> anticancer activities of complexes <b>1–8</b> have been studied comparatively to the uncoordinated ligands. The complexes exhibit fairly low cytotoxicities in comparison to related ferrocene-derived arene–ruthenium complexes.
Identifiants
Type de publication
journal article
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