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  4. Elimination of <i>P. berghei</i> liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity
 
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Elimination of <i>P. berghei</i> liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity

Auteur(s)
Renggli, J.
Hahne, M.
Matile, Hughe
Betschart, Bruno 
Institut de biologie 
Tschopp, J.
Corradin, Giampietro
Date de parution
1997
In
Parasite Immunology, Wiley, 1997/19/3/145-148
Mots-clés
  • <i>P.berghei</i>
  • perforin
  • CD95/Apo-I
  • liver stage
  • CTL
  • <i>P.berghei</i>

  • perforin

  • CD95/Apo-I

  • liver stage

  • CTL

Résumé
Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites injected by the mosquito vector, while liver stages are the target of a cellular immune response which is mediated by T cells. In this study, we evaluated the T-cell dependent protection induced by the injection of <i>P. berghei</i> irradiated sporozoites and the contribution of perforin and of the receptor/ligand system CD95/CD95L, two T cell-dependent mechanisms known to mediate elimination of target cells. Wild type, perforin deficient, CD95 mutant, CD95L mutant and perforin deficient/CD95L mutant mice were immunized with <i>P. berghei</i> irradiated sporozoites and submitted to a challenge with infectious sporozoites. All mice immunized with <i>P. berghei</i> irradiated sporozoites were protected against a sporozoite challenge, including perforin deficient/CD95L mutant animals. These results indicate that T cells do not kill malaria-infected hepatocytes via one of the known pathways, but rather that activated parasite-specific T cells produce cytokines which activate in cascade other mechanisms responsible for the intracellular elimination of the parasite.
Identifiants
https://libra.unine.ch/handle/123456789/15212
_
10.1046/j.1365-3024.1997.d01-190.x
Type de publication
journal article
Dossier(s) à télécharger
 main article: Renggli_J._-_Elimination_of_P._berghei_liver_stages_20090630.pdf (388.36 KB)
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