Synthesis of novel and stable 5-aminolevulinic acid derivatives for the efficient synthesis of 5-aminolevulinic acid based prodrugs
Author(s)
Vallinayagam, Ramakrishnan
Bertschy, Hugo
Berger, Yann
Wenger, Virginie
Date issued
2007
In
Synthesis
Vol
23
From page
3731
To page
3735
Subjects
Esters Role: SPN (Synthetic preparation) PREP (Preparation) (aliphatic prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation hydrogenation Boc-protection demethylation and esterification with pentafluorophenol trichloroethanol or acetone oxime) Esterification (prepn. of aminolevulinic acid derivs. via bromination/methylation of oxopentanoic acid followed by azidation hydrogenation Boc-protection demethylation and esterification with pentafluorophenol trichloroethanol or acetone oxime) aminolevulinic acid deriv prepn
Abstract
The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chem. transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields. [on SciFinder(R)]
Publication type
journal article