Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Author(s)
Mattsson, Johan
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Štěpnička, Petr
Date issued
2011
In
The Plant Cell, American Society of Plant Biologists
Vol
23
No
11
From page
3911
To page
3928
Abstract
The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC<sub>50</sub> ≤ 6 μM) than the 4,4-bipyridine analogues (IC<sub>50</sub> ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size of the rectangle.
Publication type
journal article
Identifiers
https://libra.unine.ch/handle/20.500.14713/65878
DOI
10.1021/om900359j
File(s)
Loading...
Thumbnail Image
Download
Name

Mattsson_Johan_-_Synthesis_Molecular_Structure_and_Anticancer_20170623.pdf

Type

Main Article

Size

1.81 MB

Format

Adobe PDF