Sawhorse-type diruthenium tetracarbonyl complexes containing biologically relevant acids
Author(s)
Johnpeter, Justin P.
Date issued
2013
In
Inorg. Chim. Acta
No
394
From page
723
To page
728
Subjects
ruthenium carbonyl probenecid indomethacin sulindac dinuclear complex prepn structure crystal structure ruthenium carbonyl probenecid indomethacin sulindac dinuclear complex
Abstract
The reaction between the biol. active acids probenecid (HO2CC12H18NO2S), indomethacin (HO2CC18H15ClNO2) and sulindac (HO2CC19H16FOS) with Ru3(CO)12, followed by addn. of axial ligands (L), such as pyridine, triphenylphosphine, or 5-(4-pyridyl)-10,15,20-triphenylporphyrin, generates stable diruthenium tetracarbonyl complexes Ru2(CO)4(?2-?2-O2CC12H18NO2S)2L2, Ru2(CO)4(?2-?2-O2CC18H15ClNO2)2L2 and Ru2(CO)4(?2-?2-O2CC19H16FOS)2L2, resp. The mol. structure of [Ru2(CO)4(?2-?2-O2CC6H4-p-SO2NPr2)(py)2]·C6H6 (1a·C6H6) was solved by single-crystal x-ray structure anal. and a typical diruthenium tetracarbonyl backbone bridged by the carboxylato ligands and two axial triphenylphosphine ligands was revealed. The benzene mol. sits between two probenecid units, and is involved in ?-stacking interactions with the arom. part of probenecid. Despite the presence of biol. relevant derivs. and carbonyl groups within the sawhorse-type dinuclear complexes, all systems show no cytotoxicity towards human cancer cells, presumably due to the high lipophilicity of these neutral complexes. [on SciFinder(R)]
Publication type
journal article