The "complex-in-a-complex" cations [(acac)2M?Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells
Author(s)
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Date issued
2008
In
Angew. Chem., Int. Ed.
Vol
20
No
47
From page
3773
To page
3776
Subjects
hydroxyquinolato bridged cymene ruthenium pyridinyltriazine complex prepn reaction palladium platinum acetylacetonate hydroxyquinolato bridged cymene ruthenium binuclear prepn antitumor activity palladium platinum acetylacetonate hydroxyquinolato bridged cymene ruthenium crystal mol structure platinum acetylacetonate hydroxyquinolato bridged cymene ruthenium
Abstract
The cytotoxicities of the large cationic arene-ruthenium prismatic cage [Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinolato; 16+), and its "complex-in-a-complex" derivs. [(acac)2M-1]6+ (M = Pd, Pt; acac = acetylacetonate), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a "Trojan Horse", leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect. [on SciFinder(R)]
Publication type
journal article