Inhibition of porphobilinogen synthase (PBG-synthase) by 4,6-dioxoheptanoic acid and related compounds
Author(s)
Stauffer, Frederic
Jarret, Caroline
Engeloch, Thomas
Henz, Matthias
Bobalova, Janette
Date issued
1998
In
ECHET98 Electron. Conf. Heterocycl. Chem.
From page
459
To page
465
Subjects
Enzyme kinetics (inhibition of porphobilinogen synthase (PBG-synthase) by 4 6-dioxoheptanoic acid (1) and related compds.) porphobilinogen synthase inhibition dioxoheptanoate kinetics
Abstract
We are investigating the mechanism of PBG-synthase by active site directed inhibition studies. The procedure for testing and the data obtained with compds. related to 4,6-dioxoheptanoic acid are reported and the results are discussed in the context of our kinetic model. [on SciFinder(R)]
Publication type
journal article