The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicylaldiminato) metallodendrimers
Author(s)
Govender, Preshendren
Sudding, Lara C.
Clavel, Catherine M.
Dyson, Paul J.
Smith, Gregory S.
Date issued
2013
In
Dalton Trans.
Vol
4
No
42
From page
1267
To page
1277
Subjects
ruthenium complex acrylonitrile dendrimer antitumor agent antiproliferative salicylaldiminato metallodendrimer
Abstract
Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesized and characterized using NMR and IR spectroscopy, elemental anal. and MALDI-TOF/HR-ESI mass spectrometry. Metallodendrimers from the first to the fourth-generation contg. up to 32 peripheral ruthenium-arene-PTA moieties were obtained. Model mononuclear analogs, [{Ru(?6-p-cymene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6] and [{Ru(?6hexamethylbenzene)((C7H5NO)-?2-N,O)(PTA)}((CH2)3)][PF6], have been prepd. and their structures were detd. by single crystal X-ray diffraction anal. The cytotoxicities of the metallodendrimers and their mononuclear analogs were established on A2780 and A2780cisR human ovarian carcinoma cancer cells and model human embryonic kidney (HEK) cells. [on SciFinder(R)]
Publication type
journal article