Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin-ruthenium metalla-cubes
Author(s)
Schmitt, Frederic
Barry, Nicolas P. E.
Juillerat-Jeanneret, Lucienne
Date issued
2012
In
Bioorg. Med. Chem. Lett.
Vol
1
No
22
From page
178
To page
180
Subjects
photodynamic therapy cancer chemotherapeutic porphyrin ruthenium metalla cube
Abstract
Two cationic octanuclear metalla-cubes [Ru8(?6-C6H5Me)8(tpp-H2)2(dhbq)4]8+ and [Ru8(?6-p-iPrC6H4Me)8(tpp-H2)2(dhbq)4]8+ were prepd. and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1 ?M concn., LD50 = 2-7 J/cm2), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers. [on SciFinder(R)]
Publication type
journal article