Options
Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds
Auteur(s)
Govender, Preshendren
Antonels, Nathan C.
Mattsson, Johan
Renfrew, Anna K.
Dyson, Paul J.
Moss, John R.
Smith, Gregory S.
Date de parution
2009
In
J. Organomet. Chem.
Vol.
21
No
694
De la page
3470
A la page
3476
Résumé
The rational development of multinuclear arene ruthenium complexes (arene = p-cymene, hexamethylbenzene) from generation 1 (G1) and generation 2 (G2) of 4-iminopyridyl based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (n = 4 or 8, DAB = diaminobutane) has been accomplished in order to exploit the enhanced permeability and retention' (EPR) effect that allows large mols. to selectively enter cancer cells. Four compds. were synthesized, i.e. [{(p-cymene)RuCl2}4G1] (1), [{(hexamethylbenzene)RuCl2}4G1] (2), [{(p-cymene)RuCl2}8G2] (3), and [{(hexamethylbenzene)RuCl2}8G2] (4), by first reacting DAB-(NH2)n with 4-pyridinecarboxaldehyde and subsequently metalating the iminopyridyl dendrimers with [(p-cymene)RuCl2]2 or [(hexamethylbenzene)RuCl2]2. The related mononuclear complexes [(p-cymene)RuCl2(L)] (5) and [(hexamethylbenzene)RuCl2(L)] (6) were obtained in a similar manner from N-(pyridin-4-ylmethylene)propan-1-amine (L). The mol. structure of 5 has been detd. by x-ray diffraction anal. and the in vitro anticancer activities of the mono-, tetra- and octanuclear complexes 1-6 studied on the A2780 human ovarian carcinoma cell line showing a close correlation between the size of the compd. and cytotoxicity. [on SciFinder(R)]
Type de publication
Resource Types::text::journal::journal article
