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Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages
Auteur(s)
Pitto-Barry, Anais
Zava, Olivier
Dyson, Paul J.
Date de parution
2012
In
Inorg. Chem.
Vol.
13
No
51
De la page
7119
A la page
7124
Mots-clés
Résumé
Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrGn) or alc. (pyrGn-OH) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic mols. was encapsulated in the arene ruthenium metallacages, [Ru6(p-cymene)6(OO?OO)3(tpt)2]6+ (OO?OO = 5,8-dioxydo-1,4-naphtaquinonato (donq) [1]6+ and 6,11-dioxydo-5,12-naphtacenedionato (dotq) [2]6+; tpt =2,4,6-tri(pyridin-4-yl)-1,3,5-triazine). The host-guest properties of [guest?1]6+ and [guest?2]6+ were studied in soln. by NMR and UV-vis spectroscopic methods, thus allowing the detn. of the affinity consts. Moreover, the cytotoxicity of these water-sol. host-guest systems and the pyrenyl-dendrimers was evaluated on human ovarian cancer cells. [on SciFinder(R)]
Type de publication
Resource Types::text::journal::journal article
