Functionalised Arene-Ruthenium Complexes: Bridging the Gap from Bio- to Nano-Materials
Responsable du projet Bruno Therrien
Georg Süss Fink
Résumé This interdisciplinary research project is based around the development of arene-ruthenium complexes. So far, the research on arene-ruthenium complexes has been mainly concentrated around ligands directly attached to the ruthenium atom, the arene moiety playing only a minor role. Therefore, introducing functionalised moieties to the coordinated arene ligand opens the door to the generation of new compounds which can be used for various applications. The project is intended to exploit the potential of functionalised arene-ruthenium complexes in mainly two fields: As biological active compounds and as building block in the construction of nano-materials. The bio-inorganic part will focus on the synthesis of specific targeted complexes which incorporate bio-active unit. These mono-functionalised arene-ruthenium complexes possessing a bio-sensor will find application primarily as anticancer and antiviral agents. The synthetic work will be carried out in Neuchâtel and the biological activity will be performed in collaboration with the laboratory of Prof. Dyson in Lausanne. The nano-materials part implies the synthesis of multi-functionalised arene-ruthenium building blocks which will be used in the preparation of more elaborated architectures such as polymers, dendrimers, squares, grids or capsules. The synthetic work and the characterisation of the products will be carried out in Neuchâtel and some properties will be studied in France within the group of Dr. Chérioux or in the Czech Republic within the group of Dr. Petr Štěpnička. The present research project is laid out for several years and shall be carried out by Ph. D. students.
Mots-clés Cancer, Drug, Ligand design, Organo-ruthenium, Nano-materials, Supramolecular chemistry, Arene-ruthenium complexes, ligands; metal-based drugs
Type de projet Recherche fondamentale
Domaine de recherche Chimie inorganique
Source de financement FNS - Encouragement de projets (Div. I-III)
Etat Terminé
Début de projet 1-4-2006
Fin du projet 31-3-2008
Budget alloué 104'538.00
Contact Bruno Therrien