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Water-Soluble Ruthenium Complexes and Nanoparticles for Catalysis and Tumor Targeting
Responsable du projet Georg Süss Fink
   
Collaborateur Bing Sun
Jiri Tauchman
   
Résumé The present research project focuses on the synthesis and characterization of water-soluble ruthenium complexes and ruthenium nanoparticles, with the aim of exploiting their inherent catalytic or biolo­gical potential.

Background

Although being the cheapest of all noble metals, ruthenium had almost no indu­strial applica­ti­ons until recently. It was only scarcely used in catalytic reactions, until the dis­covery of high­ly enan­tio­selective ruthenium-based hydrogenation catalysts by Noyori and of effi­cient ruthe­ni­um-based olefin metathesis catalysts by Grubbs; these major discoveries led to the Nobel pri­­zes of 2001 and 2005. On the other hand, the development of dye-sensitized solar cells on the ba­sis of ruthenium complexes by Grätzel, awarded by the Millenium Tech­no­­logy Prize 2010, showed ruthenium to be interesting for light-harvesting processes. In addition, ruthe­ni­um tur­ned out to be the most promising metal to re­place platinum in the chemotherapy of cancer, follo­wing the land­mark discoveries of Kepp­ler and Sava. All these recent findings sti­mu­lated the coordi­na­tion chemistry of ruthenium, which has now become one of the most in­te­resting metals for future applications.

Aim

Within this project, we propose to work on three main topics involving a PhD stu­dent and a post-doctoral research associate: Highly Cytotoxic Dinuclear Arene Ruthenium Complexes Containing Thiolato Bridges, Catalysis with Hectorite- or Magnetite-Supported Ruthe­nium Nanoparticles, Photodynamic Porphyrin and Chlorin Conjugates of Trinuclear Ruthenium Complexes

Significance

While water-soluble organometallics in general are still very rare, arene ruthenium com­plexes with this particular property, the chemistry of which we have pioneered, open new perspectives for use as catalysts in aqueous solution and as potential anticancer drugs.
   
Mots-clés Anticancer properties, Hectorite support, Water-soluble organometallics, Magnetite support, Catalysis, Ruthenium, Nanoparticles
   
Type de projet Recherche fondamentale
Domaine de recherche Chimie inorganique
Source de financement FNS - Encouragement de projets (Div. I-III)
Etat Terminé
Début de projet 1-1-2013
Fin du projet 31-12-2015
Budget alloué 263'091.00
Contact Georg Süss-Fink