Water-Soluble Arene Ruthenium Complexes
| Project responsable | Georg Süss Fink |
| Team member |
Michael Gras
Marie Anne Flore Ibao Julien Freudenreich |
| Abstract |
The present research project focuses on the synthesis and structural
characterization of new di- and multinuclear arene ruthenium
complexes that are soluble in water and inert towards hydrolysis,
with the aim of exploiting their inherent catalytic or biological
potential. Background Although being the cheapest of all noble
metals, ruthenium has almost no industrial application and was only
scarcely used in catalytic reactions, until the discovery of highly
enantioselective ruthenium-based hydrogenation catalysts by R.
Noyori and of efficient ruthenium-based olefin metathesis catalysts
by R. H. Grubbs. These two major discoveries led to the Nobel prizes
of 2001 and 2005 and also stimulated the coordination chemistry of
ruthenium. Aim Within this project, we propose to work on two main
topics involving two Ph. D. students: Dinuclear Arene Ruthenium
Complexes with Thiolato and Selenolato Bridges as well as Arene
Ruthenium Cages with Various Tritopic Connecting Units.
Significance While water-soluble organometallics in general are
still very rare, arene ruthenium complexes with this particular
property, the chemistry of which we have pioneered, open new
perspectives for use as catalysts in aqueous solution and as
potential anti-cancer drugs. Keywords Ruthenium, Dinuclear
complexes, Trinuclear clusters, Arene ruthenium cages, Catalysis,
Water-soluble organometallics, Anti-cancer properties |
| Keywords |
Dinuclear complexes, Trinuclear clusters, Hexanuclear cages, Catalysis, Water-soluble organometallics, Ruthenium, Anticancer properties, Arene ruthenium cages, Anti-cancer properties |
| Type of project | Fundamental research project |
| Research area | Chimie inorganique |
| Method of financing | FNS - Encouragement de projets (Div. I-III) |
| Status | Completed |
| Start of project | 1-10-2010 |
| End of project | 30-9-2012 |
| Overall budget | 242'020.00 |
| Additional info |
http://p3.snf.ch/projects-131844# |
| Contact | Georg Süss-Fink |