Water-Soluble Arene Ruthenium Complexes
| Responsable du projet | Georg Süss Fink |
| Collaborateur |
Marie Anne Flore Ibao
Julien Freudenreich Trieu Tien Thai |
| Résumé |
The present research project focuses on the synthesis and structural
characterization of new mono- and multinuclear arene ruthenium
complexes that are soluble in water and inert towards hydrolysis,
with the aim of exploiting their inherent catalytic or biological
potential. Background Although being the cheapest of all noble
metals, ruthenium has almost no industrial application and was only
scarcely used in catalytic reactions, until the discovery of highly
enantioselective ruthenium-based hydrogenation catalysts by R.
Noyori and of efficient ruthenium-based olefin metathesis catalysts
by R. H. Grubbs. These two major discoveries led to the Nobel prizes
of 2001 and 2005 and also stimulated the coordination chemistry of
ruthenium. Aim Within this project, we propose to work on three
main topics involving three Ph. D. students: Mononuclear arene
ruthenium complexes containing N,O-chelating ligands as catalysts
in aqueous solution, Trinuclear arene ruthenium clusters with
biologically active substitutents for anti-cancer drug development,
and Bimetallic arene ruthenium-tin complexes for various catalytic
applications. Significance While water-soluble organometallics in
general are still very rare, arene ruthenium complexes with this
particular property, the chemistry of which we have pioneered, open
new perspectives for use as catalysts in aqueous solution and as
potential anti-cancer drugs. |
| Mots-clés |
Ruthenium, Mononuclear complexes, Trinuclear clusters, Bimetallic Complexes, Tin, Catalysis, Water-soluble organometallics, Hydrogenation, Anti-cancer properties |
| Type de projet | Recherche fondamentale |
| Domaine de recherche | Chimie inorganique |
| Source de financement | FNS - Encouragement de projets (Div. I-III) |
| Etat | Terminé |
| Début de projet | 1-10-2008 |
| Fin du projet | 30-9-2010 |
| Budget alloué | 303'685.00 |
| Autre information |
http://p3.snf.ch/projects-121509# |
| Contact | Georg Süss-Fink |