Water-Soluble Ruthenium Complexes and Nanoparticles for Catalysis and Tumor Targeting
| Responsable du projet | Georg Süss Fink |
| Collaborateur |
Bing Sun
Jiri Tauchman |
| Résumé |
The present research project focuses on the synthesis and
characterization of water-soluble ruthenium complexes and ruthenium
nanoparticles, with the aim of exploiting their inherent catalytic
or biological potential. Background Although being the cheapest of all noble metals, ruthenium had almost no industrial applications until recently. It was only scarcely used in catalytic reactions, until the discovery of highly enantioselective ruthenium-based hydrogenation catalysts by Noyori and of efficient ruthenium-based olefin metathesis catalysts by Grubbs; these major discoveries led to the Nobel prizes of 2001 and 2005. On the other hand, the development of dye-sensitized solar cells on the basis of ruthenium complexes by Grätzel, awarded by the Millenium Technology Prize 2010, showed ruthenium to be interesting for light-harvesting processes. In addition, ruthenium turned out to be the most promising metal to replace platinum in the chemotherapy of cancer, following the landmark discoveries of Keppler and Sava. All these recent findings stimulated the coordination chemistry of ruthenium, which has now become one of the most interesting metals for future applications. Aim Within this project, we propose to work on three main topics involving a PhD student and a post-doctoral research associate: Highly Cytotoxic Dinuclear Arene Ruthenium Complexes Containing Thiolato Bridges, Catalysis with Hectorite- or Magnetite-Supported Ruthenium Nanoparticles, Photodynamic Porphyrin and Chlorin Conjugates of Trinuclear Ruthenium Complexes Significance While water-soluble organometallics in general are still very rare, arene ruthenium complexes with this particular property, the chemistry of which we have pioneered, open new perspectives for use as catalysts in aqueous solution and as potential anticancer drugs. |
| Mots-clés |
Anticancer properties, Hectorite support, Water-soluble organometallics, Magnetite support, Catalysis, Ruthenium, Nanoparticles |
| Type de projet | Recherche fondamentale |
| Domaine de recherche | Chimie inorganique |
| Source de financement | FNS - Encouragement de projets (Div. I-III) |
| Etat | Terminé |
| Début de projet | 1-1-2013 |
| Fin du projet | 31-12-2015 |
| Budget alloué | 263'091.00 |
| Contact | Georg Süss-Fink |