Functionalised Arene-Ruthenium Complexes: Bridging the Gap from Bio- to Nano-Materials
| Responsable du projet |
Bruno Therrien
Georg Süss Fink |
| Résumé |
This interdisciplinary research project is based around the
development of arene-ruthenium complexes. So far, the research on
arene-ruthenium complexes has been mainly concentrated around
ligands directly attached to the ruthenium atom, the arene moiety
playing only a minor role. Therefore, introducing functionalised
moieties to the coordinated arene ligand opens the door to the
generation of new compounds which can be used for various
applications. The project is intended to exploit the potential of
functionalised arene-ruthenium complexes in mainly two fields: As
biological active compounds and as building block in the
construction of nano-materials. The bio-inorganic part will focus
on the synthesis of specific targeted complexes which incorporate
bio-active unit. These mono-functionalised arene-ruthenium
complexes possessing a bio-sensor will find application primarily
as anticancer and antiviral agents. The synthetic work will be
carried out in Neuchâtel and the biological activity will be
performed in collaboration with the laboratory of Prof. Dyson in
Lausanne. The nano-materials part implies the synthesis of
multi-functionalised arene-ruthenium building blocks which will be
used in the preparation of more elaborated architectures such as
polymers, dendrimers, squares, grids or capsules. The synthetic
work and the characterisation of the products will be carried out
in Neuchâtel and some properties will be studied in France
within the group of Dr. Chérioux or in the Czech Republic
within the group of Dr. Petr Štěpnička. The
present research project is laid out for several years and shall be
carried out by Ph. D. students. |
| Mots-clés |
Cancer, Drug, Ligand design, Organo-ruthenium, Nano-materials, Supramolecular chemistry, Arene-ruthenium complexes, ligands; metal-based drugs |
| Type de projet | Recherche fondamentale |
| Domaine de recherche | Chimie inorganique |
| Source de financement | FNS - Encouragement de projets (Div. I-III) |
| Etat | Terminé |
| Début de projet | 1-4-2006 |
| Fin du projet | 31-3-2008 |
| Budget alloué | 104'538.00 |
| Contact | Bruno Therrien |