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Supramolecular Assemblies from Ruthenium Complexes
Responsable du projet Bruno Therrien
   
Collaborateur Justin John Peter
   
Résumé Adding functionality to coordination complexes is essential to generate supramolecular compounds with intrinsic properties, such as host-guest chemistry, cavity-directed synthesis and cavity-controlled catalysis, photoluminescence, redox active materials, magnetic compounds, photo- and electro-chemical sensors or as biologically active agents. In order to prepare such functionalised-systems, synthetic chemists must control the relative arrangement, with respect to each other, of each single element of the final architectures. Thus, employing coordination chemistry using functional ligands and organometallic complexes offers several advantages: i) functionalities can be introduced on either the ligands or the metal centres; ii) upon formation of the superstructures, these different centres may interact to lead to a higher level of functionality; iii) macrocycles and cages containing transition metals are generally more sensitive and responsive to electro- and photochemical stimuli as compared to metal-free organic structures. Consequently, the present project intends to use various organometallic ruthenium building blocks to generate new metalla-assemblies with new properties and to explore new applications. In recent years we have found new applications for sawhorse-type diruthenium complexes. Traditionally used as catalysts, we have now utilised these dinuclear complexes as building blocks in supramolecular chemistry and as chemotherapeutic agents. Mr. JOHNPETER has joined my group two years ago, with a grant from the Federal Commission of Fellowship for studies in Neuchâtel. He has been granted a second year, which is the limit of their scheme, but which is not sufficient to finish his PhD. In order to complete his PhD in Neuchatel and to further investigate the chemistry of sawhorse-type complexes, two years of funding is seeking. In addition, introduction of arene ruthenium building blocks in the synthesis of supramolecular metalla-assemblies and metalla-cages has been successfully exploited in our group over the last 7 years [FNS 200020-119760; 200021-111795; 200021-113282; 200020-129518]. These compounds have opened new perspectives for biological and nano-applications (sensors, drug delivery agents, chemotherapeutics, tweezers) and therefore we would like to further explore this chemistry with a view to generate new families of supramolecular assemblies and to search for new applications. Moreover, extension of this chemistry to other metal centres is envisaged in the proposal. Therefore, two new PhD candidates are seeking to synthesise and characterise these promising systems containing half-sandwich complexes and to study their properties.
   
Mots-clés Bioinorganic, Ruthenium, Supramolecular Assemblies, Chemotherapeutic Agents, Metallacages
   
Type de projet Recherche fondamentale
Domaine de recherche Chimie inorganique
Source de financement FNS - Encouragement de projets (Div. I-III)
Etat Terminé
Début de projet 1-5-2012
Fin du projet 30-4-2014
Budget alloué 153'440.00
Autre information http://p3.snf.ch/projects-140212#
Contact Bruno Therrien